Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in young adults with refractory epilepsy having an incidence rate of 24-fold higher than control populations and accounting for an average of 17% of deaths in patients with epilepsy. It is clinically characterized by recurrent seizures caused by an imbalance between cerebral excitability and inhibition in the central nervous system (CNS) which may either affect specific brain systems or originate in a restricted area and spread to involve multiple cortical and subcortical circuits. Our findings provided evidence that changes in cardiac morphology may be related to autonomic CV dysfunctions occurring during SUDEP while also opening up more avenues to better develop novel drugs for the treatment of this disorder.Įpilepsy is a group of chronic neurological disorders with a complex etiology and represents one of the most common serious brain conditions, affecting over 70 million people worldwide. A significantly decreased distance between atria and a significant increase in heart weight were observed in PTZ-kindled rats which interestingly also displayed increased hemorrhagic content when compared with controls. To complete this, the distance between the atria, between the atrium and ventricle were measured, the heart was weighed, and the pathological morphology of dissected hearts was analyzed by histological assessment with hematoxylin and eosin staining. Therefore, we aimed to examine the cardiac morphological alterations in a pentylenetetrazol (PTZ)-kindled rat model, a well-established tool for studying chronic epilepsy. SUDEP patients displayed an increased cardiovascular (CV) risk, probably due to an impaired autonomic control of CV functions, but the underlying mechanisms need to be explored yet. Sudden unexpected death in epilepsy (SUDEP) is the predominant cause of death in young epileptic patients. Epilepsy is a group of neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation.
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